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Table 2: Metabolite concentrations in cerebral white matter of 7 patients with X-ALD and 14 controls (in vivo)
Center of Lesion (mean) Edge of Lesion (mean) NAWM (mean) Controls (mean)
MTR (%) 11.5 ± 3.3^a 23.0 ± 1.5^a 29.0 ± 2.5 31.8 ± 1.5
ADC (10⁻³ mm²/s) 2.1 ± 0.4^a 1.2 ± 0.5^a 0.83 ± 0.05 0.81 ± 0.07
FA 0.20 ± 0.04^a 0.30 ± 0.05^a 0.43 ± 0.02 0.37 ± 0.04^a
tCr (mmol/L) 2.7 ± 0.9^a 4.3 ± 0.5 4.8 ± 1.0 4.5 ± 0.6
tNAA (mmol/L) 1.9 ± 1.8^a 4.9 ± 1.9^a 7.2 ± 0.9 7.7 ± 1.0
Cho (mmol/L) 1.4 ± 0.9 1.9 ± 0.3^b 1.5 ± 0.4 1.3 ± 0.2
mIns (mmol/L) 5.0 ± 1.5^a 4.8 ± 0.6^a 4.2 ± 1.1 3.6 ± 0.3
Lac (mmol/L) 1.8 ± 2.0^a 2.3 ± 2.5^b 0.5 ± 0.6 0.2 ± 0.3
a Significantly different from NAWM (P< .01).
b Significantly different from NAWM and center of lesion (P< .01).

	Center of Lesion (mean)	Edge of Lesion (mean)	NAWM (mean)	Controls (mean)
MTR (%)	11.5 ± 3.3^a	23.0 ± 1.5^a	29.0 ± 2.5	31.8 ± 1.5
ADC (10⁻³ mm²/s)	2.1 ± 0.4^a	1.2 ± 0.5^a	0.83 ± 0.05	0.81 ± 0.07
FA	0.20 ± 0.04^a	0.30 ± 0.05^a	0.43 ± 0.02	0.37 ± 0.04^a
tCr (mmol/L)	2.7 ± 0.9^a	4.3 ± 0.5	4.8 ± 1.0	4.5 ± 0.6
tNAA (mmol/L)	1.9 ± 1.8^a	4.9 ± 1.9^a	7.2 ± 0.9	7.7 ± 1.0
Cho (mmol/L)	1.4 ± 0.9	1.9 ± 0.3^b	1.5 ± 0.4	1.3 ± 0.2
mIns (mmol/L)	5.0 ± 1.5^a	4.8 ± 0.6^a	4.2 ± 1.1	3.6 ± 0.3
Lac (mmol/L)	1.8 ± 2.0^a	2.3 ± 2.5^b	0.5 ± 0.6	0.2 ± 0.3