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Main demographic, clinical, and structural MR imaging characteristics of patients with fatigued and nonfatigued MS and HC
HC Nonfatigued MS Fatigued MS
No. of subjects 14 14 10
Women/men 8/6 8/6 6/4
Mean age (yr) 38.7 ± 8.4 38.6 ± 8.5 38.0 ± 7.7
Mean disease duration (yr) – 10.6 ± 6.6 8.2 ± 6.2
Median EDSS (range) 1.5 (0–1.5) 1.5 (1.5–2.0)
Mean FSS (range) – 2.1 (1.4–3.3) 4.4 (4–6.1)
Median T2 LV (mL) – 8.9 ± 10.7 7.7 ± 5.0
Mean NBV (mL) 1649 ± 48 1560 ± 51 1596 ± 79
Mean WMV (mL) 822 ± 42 790 ± 60 801 ± 55
Mean GMV (mL) 826 ± 58 770 ± 45 795 ± 66

	HC	Nonfatigued MS	Fatigued MS
No. of subjects	14	14	10
Women/men	8/6	8/6	6/4
Mean age (yr)	38.7 ± 8.4	38.6 ± 8.5	38.0 ± 7.7
Mean disease duration (yr)	–	10.6 ± 6.6	8.2 ± 6.2
Median EDSS (range)		1.5 (0–1.5)	1.5 (1.5–2.0)
Mean FSS (range)	–	2.1 (1.4–3.3)	4.4 (4–6.1)
Median T2 LV (mL)	–	8.9 ± 10.7	7.7 ± 5.0
Mean NBV (mL)	1649 ± 48	1560 ± 51	1596 ± 79
Mean WMV (mL)	822 ± 42	790 ± 60	801 ± 55
Mean GMV (mL)	826 ± 58	770 ± 45	795 ± 66