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Table 4: Linear regression between ICARS total score and CNS volumes: simple linear regression and linear regression including disease duration as a covariate
SCA Linear Regression Type Coefficient B (95% CI) R² P
Cerebellar volume 3 Simple −0.341 (−0.631 to −0.543) 0.29 .024^a
Including DD −0.19 (−0.50 to −0.11) 0.46 .20
6 Simple −0.407 (−0.758 to −0.057) 0.30 .026^a
Including DD −0.33 (−0.76 to −0.14) 0.31 .15
Brain stem volume 3 Simple −2.01 (−3.141 to −0.879) 0.49 .002^b
Including DD −1.51 (−2.7 to −0.31) 0.60 .02^a
6 Simple −2.732 (−4.626 to −0.837) 0.39 .008^b
Including DD −2.37 (−4.3 to −0.44) 0.46 .02^a
a Significant with P < .05
b Significant with P < .01.

	SCA	Linear Regression Type	Coefficient B (95% CI)	R²	P
Cerebellar volume	3	Simple	−0.341 (−0.631 to −0.543)	0.29	.024^a
		Including DD	−0.19 (−0.50 to −0.11)	0.46	.20
	6	Simple	−0.407 (−0.758 to −0.057)	0.30	.026^a
		Including DD	−0.33 (−0.76 to −0.14)	0.31	.15
Brain stem volume	3	Simple	−2.01 (−3.141 to −0.879)	0.49	.002^b
		Including DD	−1.51 (−2.7 to −0.31)	0.60	.02^a
	6	Simple	−2.732 (−4.626 to −0.837)	0.39	.008^b
		Including DD	−2.37 (−4.3 to −0.44)	0.46	.02^a