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Table 2: Patient characteristics by time to IV tPA initiation
Characteristic ≤60 Minutes to tPA (n = 67) >60 Minutes to tPA (n = 56) P Value
Multimodal CT imaging 92.5 (62) 82.1 (46) .08
Age ≥65 68.7 (46) 66.1 (37) .76
Female sex 59.7 (40) 58.9 (33) .93
Prehospital stroke notification 89.6 (60) 73.2 (41) .02^a
Peak arrival time (12pm to 12 am) 43.3 (29) 35.7 (20) .39
Weekday arrival (Monday–Friday) 67.2 (45) 73.2 (41) .47
Initial NIHSS score ≥ 8 68.2 (45) 53.7 (29) .10
Onset-to-arrival time^a 50 (35–83) 44 (35–63) .10
Arrival to CT start time^a 10 (6–15) 14 (9–26) .01
Door-to-needle time^b 43 (37–50) 83.5 (70–95) <.001
Year^b .25
    2006 34.3 (23) 28.6 (16) 
    2007 34.3 (23) 28.6 (16) 
    2008 31.4 (21) 42.9 (24) 
a Event times are shown as median (IQR).
b Cochran-Armitage test for trend.

Characteristic	≤60 Minutes to tPA (n = 67)	>60 Minutes to tPA (n = 56)	P Value
Multimodal CT imaging	92.5 (62)	82.1 (46)	.08
Age ≥65	68.7 (46)	66.1 (37)	.76
Female sex	59.7 (40)	58.9 (33)	.93
Prehospital stroke notification	89.6 (60)	73.2 (41)	.02^a
Peak arrival time (12pm to 12 am)	43.3 (29)	35.7 (20)	.39
Weekday arrival (Monday–Friday)	67.2 (45)	73.2 (41)	.47
Initial NIHSS score ≥ 8	68.2 (45)	53.7 (29)	.10
Onset-to-arrival time^a	50 (35–83)	44 (35–63)	.10
Arrival to CT start time^a	10 (6–15)	14 (9–26)	.01
Door-to-needle time^b	43 (37–50)	83.5 (70–95)	<.001
Year^b			.25
2006	34.3 (23)	28.6 (16)
2007	34.3 (23)	28.6 (16)
2008	31.4 (21)	42.9 (24)