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Table 3: Univariate logistic regression analysis of the predictive value of thalamic volumetry and DTI findings from the GM with and without the thalamus for patients with EDSS scores worsening during 5 years (dependent variable)^a
Independent Variables Units OR (95% CI) PValues
Baseline NTV 1 mL 1.25 (0.63–2.45) .53
Baseline thalamic FA 0.01 0.99 (0.97–1.02) .57
Baseline thalamic MD 0.01 mm²/s × 10⁻³ 1.02 (0.98–1.06) .40
Average NTV thalamic volume change 1% 1.00 (0.91–1.11) .94
Average thalamic FA change 1% 0.87 (0.77–0.97) .01
Average thalamic MD change 1% 1.04 (0.97–1.11) .27
Thalamic lesions n.a. 1.06 (0.66–1.68) .82
Change in thalamic lesions Yes vs no 2.23 (0.40–12.5) .36
Baseline GM without the thalami FA 0.01 1.02 (0.99–1.06) .22
Baseline GM without the thalami MD 0.01 mm²/s ×10⁻³ 1.14 (1.02–1.27) .019
Average GM without the thalami FA change 1% 0.99 (0.93–1.05) .63
Average GM without the thalami MD change 1% 1.03 (0.92–1.15) .64

a See the text for statistical analysis.