Table 3:

MR imaging signs in 36 patients with IH and 36 control subjects^a

Patient Group	Opening CSF Pressure on LP in cm H₂O (mean) (range)		CVOO	ONS Hydrops^b	Reduced Pituitary Height (<2.6 mm)	Flattened Posterior Sclera	Optic Disc Protrusion	Dilated SOV (<2.6 mm in diameter)	Ventriculomegaly	Periventricular CSF Flow	Optic Nerve Edema	Optic Nerve Elongation	No. of Positive MRI Signs (mean) (range)
All patients	39.8	Frequency,	34/36	33/36	20/36	23/36	12/36	11/36	7/36	5/36	5/36	2/36	4.3 (2–9)
	24–70	Sensitivity,	94%	92%	56%	64%	33%	31%	19%	14%	14%	6%
		CI 95%,	81%–99%	76%–98%	38%–72%	46%–79%	19%–91%	16%–48%	8%–36%	5%–29%	5%–29%	1%–19%
		Specificity,	100%	89%	97%	78%	100%	97%	100%	100%	100%	100%
		95% CI,	90%–100%	73%–96%	85%–100%	61%–90%	90%–100%	85%–100%	90%–100%	90%–100%	90%–100%	90%–100%
		OR	1007	88	44	6	37	15	18	13	13	5
		95% CI,	47–21,741	18–424	5–355	2–17	2–658	2–127	1–338	1–240	1–240	.3–114
		Agreement,^c	100%	100%	91.7%	63.9%	77.8%	67%	91.7%	91.7%	69.4%	80.6%
		κ^c	1	1	0.888	0.484	0.675	0.338	0.852	0.79	0.47	0.533
Patient	29.5	Frequency	10/12	11/12	4/12	5/12	2/12	4/12	1/12	1/12	0/12	0/12	3.3 (2–6)
subgroup I	22–38		83%	92%	33%	42%	17%	33%	8%	8%	0%	0%
Patient	52	Frequency	10/10	9/10	7/10	8/10	6/10	3/10	3/10	1/10	3/10	1/10	5.1 (3–7)
subgroup II	40–70		100%	90%	70%	80%	60%	30%	30%	10%	30%	10%
Patient	N.T.	Frequency	14/14	13/14	9/14	10/14	4/14	4/14	3/14	3/14	2/14	1/14	4.5 (2–9)
subgroup III			100%	93%	64%	71%	29%	29%	21%	21%	14%	7%
Controls	N.T.	Frequency	0/36	4/36	35/36	8/36	0/36	1/36	0/36	0/36	0/36	0/36	0.4 (0–1)
			0%	11%	3%	22%	0%	3%	0%	0%	0%	0%
		Agreement^c	100%	78%	100%	69.4%	94.4%	94.4%	94.4%	97.2%	97.2%	94.4%

a Frequency of all MRI signs differed between patients and controls (P< .01). Frequency of the MRI signs “optic disc protrusion” and “optic nerve edema” were more often found in patient group II compared with patient group I (P< .05). Frequencies of all MRI signs did not differ between patient subgroup III and the other patient groups.
b ONS hydrops was assumed if the diameter was above normal limits in ≥1 different position. Normal upper limits of ONS diameters were 6.4, 5.8, 5.1, and 4.8 mm in measurement positions 1, 2, 3, and 4 (3, 6, 10, and 20 mm behind the globe).
c Results of 3 readers used to determine the interobserver-reliability.