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Table 1: Thalamic volumetry and DTI findings from the GM with and without the thalamus, at study entry and after 15 months in healthy controls and patients with PPMS^a
Variables Healthy Controls Patients with PPMS P Value
NTV 
    Baseline 6.11 (0.48) 4.11 (0.95) <0.001
    % Change −1.9 (3.1) −4.7 (6.2) 0.39
    P^a n.s. <.0001 
Thalamic MD 
    Baseline 0.87 (0.04) 1.08 (0.16) .002
    % Change +4.0 (8.7) +2.0 (10.2) .61
    P^b n.s. <.0001 
Thalamic FA 
    Baseline 0.23 (0.01) 0.21 (0.02) .002
    % Change −5.0 (7.1) −12.2 (7.1) .01
    P^b n.s. <.0001 
GM without thalami MD 
    Baseline 1.02 (0.04) 1.08 (0.06) .005
    % Change +1.0 (2.4) +2.0 (6.2) n.s
    P^b n.s. n.s. 
GM without thalami FA 
    Baseline 0.15 (0.06) 0.14 (0.11) n.s.
    % Change −6.1 (12.0) −16.1 (16.1) .06
    P^b n.s. .009 

a Values are means ± SDs in parentheses.

b Pair-wise comparisons versus baseline values (the text for statistical analysis).