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Main metabolite concentration ratios in the cervical spinal cord of healthy volunteers and patients with RRMS
tNAA:CrtNAA:ChoCho:CrmIns:Cr
Healthy cervical spinal cord
    Mean1.4 ± 0.33.1 ± 0.80.5 ± 0.11.7 ± 0.2
    CV (%)23261013
RRMS cervical spinal cord
    Mean1.1 ± 0.32.0 ± 0.70.6 ± 0.12.0 ± 0.4
    CV (%)32351921
    Pvalue.04.002.003.004
  • 

    Note:—RRMS indicates relapsing-remitting MS; tNAA, total N-acetylaspartate; Cr, creatine; Cho, choline; mIns; myo-inositol; CV, coefficient of variation.