Table 1:

Characteristics of included studies^a

Article	Year	Journal	Study Type	rtPA Dose/NINDS	Site of Occlusion	Recan. Assessment Tool	Recan. Times	No. of Patients With Recan.	Total No. of Relevant Patients
Noncontrast Studies^b
Alexandrov et al	2004	Stroke	Prospective cohort	Yes <180 min	M1, M2	TCD	2 h (Post-rtPA)	73	120
Daffertshofer et al	2005	Stroke	NRCT	Yes <360 min	ICA, M1, M2, M3	MRA	24 h	10	26
Derex at al	2004	Neuroradiology	Prospective cohort	No <360 min	ICA, M1, M2, ACA	MRA	24 h	28	47
Eggers at al	2003	Ann Neurol	RCT	Yes <180 min	M1, M2	TCD	1 h (Post-rtPA)	8	25
Gerriets et al	2002	Stroke	RCT (substudy of DIAS 1)	Yes <360 min	ICA, M1, M2	TCD	24 h	8	11
Kwon et al	2004	Arch Neurol	Retrospective cohort	Yes <360 min	ICA, MCA	MRA	72 h	14	20
Molina et al	2001	Stroke	Case control	Yes <180 min	M1, M2	TCD	48 h	22	24
Neumann-Haefelin et al	2004	Stroke	Retrospective cohort	NS <360 min	M1	MRA	24 h	18	52
Rubiera et al	2006	Stroke	Prospective cohort	Yes <360 min	ICA, M1, M2	TCD	2 h (Post-rtPA)	141	219
Savitz et al	2005	Stroke	Retrospective cohort	Yes <360 min	ICA, MCA	MRA	72 h	27	37
Sekoranja et al	2006	Stroke	Prospective cohort	Yes <180 min	ICA, MCA	TCD	30 min (Post-rtPA)	17	33
Yasaka et al	1998	Neurology	RCT	No 210 ± 36 min	MCA; origin, trunk, distal	TCD	24 h	8	8
Contrast Contrast studies^b
Muir et al	2005	JNNP	Prospective cohort	Yes <200 min	M1, M2	CTA, TCD, DSA	48 h	9	12
Murphy et al	2006	Stroke	Prospective cohort	NS <420 min	MCA syndrome	CTA	24 h	4	7
Wintermark et al	2006	Stroke	Prospective cohort	No <420 min	Large-artery occlusion	MRA	2–7 d	28	41
von Kummer et al	1995	Stroke	Prospective cohort	No <360 min	ICA, M1, M2	DSA	Immediately post-rtPA	19	61
Sasaki et al	1996	AJNR	Prospective cohort	No <480 min	M1, M2	DSA	24 h	1	3
Mori et al	1992	Neurology	RCT	No <360 min	ICA, M1, M2, AM	DSA	Immediately post-rtPA	9	19

Note:—Recan. indicates recanalization, JNNP, J Neurol Neurosurg Psychiatry; RCT, randomized controlled trial; NRCT, non-randomized controlled trial; CTA, CT angiography; DSA, digital subtraction angiography; MRA, MR angiography; TCD, transcranial Doppler sonography; ICA, internal carotid artery; ACA, anterior cerebral artery; MCA, middle cerebral artery; M1, M1 branch of the MCA; M2, M2 branch of the MCA; M3, M3 branch of the MCA; AM, A2 branch of the ACA; NS, not specified; rtPA, recombinant tissue plasminogen activator; DIAS I, Desmoteplase in Acute Ishemic Stroke Trial; NINDS, National Institute of Neurological Disorders and Stroke.
^a Included are data indicating whether rtPA was administered as per the protocol used in the NINDS trial.²⁴
^b All studies are listed in on-line Fig 1.