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Table 3: ROC curve analysis of PCT parameters for early response (tumor volume shrinkage ≥30%) to concomitant chemoradiotherapy
Value Criterion AUC P Sensitivity, % Specificity, % Positive LR Negative LR
Baseline BF >70.4 0.54 .4 57.3 80.0 3.0 0.6
BF (40 Gy) ≤74.4 0.82 .03 90.0 80.0 4.4 0.2
Baseline BV ≥5.0 0.83 .01 59.5 100 0.4
BV (40 Gy) ≤6.9 0.80 .02 90 80 5.2 0.0
Baseline MTT ≤9.0 0.60 .8 71.4 60 1.8 0.5
MTT (40 Gy) ≤9.2 0.83 .04 100 60 2.4 0.0
Baseline PS >10.0 0.63 .1 100 60 2.2 0.0
PS (40 Gy) ≤12.6 0.80 .06 65 100 0.4
Note:—The values of the provided criteria are the cutoff thresholds for predicting the defined early response. The statistically significant values (P ≤.05) are set in boldface italics; the values approaching statistical significance (P = .06) are set in lightface italics. Values for BF are in mL/min/100 g; for BV, mL/100 mL; for MTT, seconds; and for PS, mL/min/100 g.