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Table 1: Patient characteristics
Study Sample Validation Sample
Age≤73 Age > 73 Age > 73
CN (n = 13) aMCI (n = 13) P^{^a} CN (n = 12) aMCI (n = 12) P^{^a} CN (n = 13) aMCI (n = 10) P^{^a}
Sex 
    Female 7 (54) 6 (46) .69 6 (50) 6 (50) >.99 5 (38) 2 (20) .34 
    Male 6 (46) 7 (54) 6 (50) 6 (50) 8 (62) 8 (80) 
Age at PET scan 
    Median (IQR) 68 (66–71) 70 (63–70) .90 80 (78–82) 78 (77–82) .66 77 (76–82) 82 (78–84) .22 
    Range 57–73 55–72 75–85 74–86 74–90 76–87 
Education 
    Median (IQR) 16 (12–17) 14 (12–17) .86 12 (12–14) 14.5 (12–18.5) .20 14 (13–16) 12 (12–16) .16 
    Range 10–20 12–20 8–20 8–20 12–19 11–19 
MMSE score 
    Median (IQR) 30 (29–30) 27 (26–28) .002 29 (27–29) 27 (27–28) .08 28 (26–28) 27 (26–27) .17 
    Range 27–30 25–30 26–30 24–29 24–30 21–28 
CDR sum of boxes 
    Median (IQR) 0 (0–0) 0.5 (0.5–1.5) <.001 0 (0–0) 1.0 (0.5–2.0) <.001 0 (0–0.5) 1.3 (1.0–1.9) <.001 
    Range 0–0 0.5–2.5 0–0 0.5–3.0 0–0.5 0–3.0 
a Wilcoxon rank sum test.

	Study Sample						Validation Sample
	Age≤73			Age > 73			Age > 73
	CN (n = 13)	aMCI (n = 13)	P^{^a}	CN (n = 12)	aMCI (n = 12)	P^{^a}	CN (n = 13)	aMCI (n = 10)	P^{^a}
Sex
Female	7 (54)	6 (46)	.69	6 (50)	6 (50)	>.99	5 (38)	2 (20)	.34
Male	6 (46)	7 (54)		6 (50)	6 (50)		8 (62)	8 (80)
Age at PET scan
Median (IQR)	68 (66–71)	70 (63–70)	.90	80 (78–82)	78 (77–82)	.66	77 (76–82)	82 (78–84)	.22
Range	57–73	55–72		75–85	74–86		74–90	76–87
Education
Median (IQR)	16 (12–17)	14 (12–17)	.86	12 (12–14)	14.5 (12–18.5)	.20	14 (13–16)	12 (12–16)	.16
Range	10–20	12–20		8–20	8–20		12–19	11–19
MMSE score
Median (IQR)	30 (29–30)	27 (26–28)	.002	29 (27–29)	27 (27–28)	.08	28 (26–28)	27 (26–27)	.17
Range	27–30	25–30		26–30	24–29		24–30	21–28
CDR sum of boxes
Median (IQR)	0 (0–0)	0.5 (0.5–1.5)	<.001	0 (0–0)	1.0 (0.5–2.0)	<.001	0 (0–0.5)	1.3 (1.0–1.9)	<.001
Range	0–0	0.5–2.5		0–0	0.5–3.0		0–0.5	0–3.0