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Neuroimaging features comparing lobar versus septopreoptic HPE
Lobar Septopreoptic
Cortical nonseparation Basal frontal Septal and preoptic regions
CC Rostrum and genu absent; anterior body variably present; splenium present Rostrum absent or hypoplastic; genu hypoplastic; body and splenium present
Anterior interhemispheric fissure and falx Hypoplastic anteriorly Fairly deep IHF
Ventricles Rudimentary frontal horns; third ventricle formed Normal or small frontal horns; third ventricle formed
Dorsal cyst Absent Absent
SP Absent Present or dysplastic, rarely absent
Hypothalamus Often fused to some degree (83%) Anterior hypothalamus often fused
Cerebral vasculature Azygous anterior cerebral artery (more anteriorly displaced) Azygous anterior cerebral artery (more posteriorly placed)

	Lobar	Septopreoptic
Cortical nonseparation	Basal frontal	Septal and preoptic regions
CC	Rostrum and genu absent; anterior body variably present; splenium present	Rostrum absent or hypoplastic; genu hypoplastic; body and splenium present
Anterior interhemispheric fissure and falx	Hypoplastic anteriorly	Fairly deep IHF
Ventricles	Rudimentary frontal horns; third ventricle formed	Normal or small frontal horns; third ventricle formed
Dorsal cyst	Absent	Absent
SP	Absent	Present or dysplastic, rarely absent
Hypothalamus	Often fused to some degree (83%)	Anterior hypothalamus often fused
Cerebral vasculature	Azygous anterior cerebral artery (more anteriorly displaced)	Azygous anterior cerebral artery (more posteriorly placed)