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TABLE 2: 
Differences in slopes between patients who were younger (≤6.8 years) or older (>6.8 years) at the start of craniospinal irradiation
CC RegionAge at CSISlope*Significance†
TotalYounger−24.00.27
Older−16.0
RostrumYounger−0.60.24
Older1.0
GenuYounger−4.40.56
Older−2.4
Rostral bodyYounger−1.80.92
Older−2.0
Anterior midbodyYounger−2.20.42
Older−1.2
Posterior midbodyYounger−1.40.97
Older−1.4
IsthmusYounger−2.80.56
Older−2.0
SpleniumYounger−13.40.09
Older−4.8
  • Note.—CC indicates corpus callosum; CSI, craniospinal irradiation.
  • * Change in CC size per year since start of CSI (mm2).
  • † Testing H0: slope (reduced) = slope (conventional); P < .05, two-tailed test.