1naresh
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Information Neurodegenerative (n = 72) Leukoencephalopathy-like (n = 46)* Vascular Pattern (n = 8)* Age at diagnosis of LCH Mean 2 y 4 mo 2 y 8 mo 3 y 1 mo Range birth to 40 y birth to 40 y 1 y 5 mo to 20 y Age at diagnosis of CNS disease Mean 9 y 13 y 4 mo 13 y Range 2 y 4 mo to 52 y 2 to 47 y 3 to 22 y Chemotherapy before CNS disease No. of patients 62 32 6 Mean age 2 y 4 mo 2 y 8 mo 2 y Age range 3 to 40 y 6 mo to 40 y 1 y 5 mo to 5 y 3 mo Cranial radiotherapy before CNS disease No. of patients 15 9 1 Mean age 3 y 7 mo 5 y 6 mo 1 y 5 mo Age range 1 y 5 mo to 27 y 2 y 7 mo to 28 y Not applicable Neurologic symptoms None 18 17 0 Subtle 15 6 0 Severe 39 23 8 Observation time Mean 8 y 3 mo 8 y 6 mo 10 y 7 mo Range 1 mo to 20 y 1 mo to 20 y 3 to 17 y
* All patients had additional neurodegenerative lesions.