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TABLE 4: PCT rCBV values for the ischemic area
Group Sampling Interval
0.5 second 1 second^* 2 seconds 3 seconds 4 seconds 5 seconds 6 seconds
1 (30 mL) 
 Mean ± SD 1.0 ± 0.4 1.2 ± 0.5 1.1 ± 0.5 2.2 ± 0.4 3.7 ± 0.6 5.4 ± 1.5 12.1 ± 4.8
 Range −14.4% to +8.6% NA −10.2% to +8.5% +33.7% to +111.2% +104.2% to +335.0% +222.0% to +447.4% +630.5% to +1275.2%
 P value .018 NA .519 <.001 <.001 <.001 <.001
2 (40 mL) 
 Mean ± SD 1.1 ± 0.3 1.2 ± 0.4 1.1 ± 0.4 1.2 ± 0.4 3.2 ± 0.5 5.1 ± 0.9 10.9 ± 2.8
 Range −13.0% to +13.7% NA −10.5% to +8.1% −10.6% to +10.2% +53.0% to +220.5% +197.3% to +427.3% +510.8% to +937.3%
 P value .156 NA .076 .765 <.001 <.001 <.001
3 (50 mL) 
 Mean ± SD 0.9 ± 0.5 1.1 ± 0.3 1.0 ± 0.3 1.1 ± 0.6 2.3 ± 0.3 3.4 ± 0.5 4.3 ± 0.9
 Range −12.4% to +10.6% NA −8.1% to +8.5% −10.5% to +9.4% +33.5% to +122.3% +95.5% to +323.7% +249.7% to +435.4%
 P value .021 NA .033 .603 <.001 <.001 <.001
4 (60 mL) 
 Mean ± SD 1.0 ± 0.4 1.0 ± 0.5 0.9 ± 0.6 0.9 ± 0.4 1.1 ± 0.3 2.0 ± 0.3 2.4 ± 0.4
 Range −11.3% to +10.4% NA −7.2% to +7.2% −9.5% to +9.3% −11.8% to +12.1% +23.3% to +155.9% +97.9% to +228.1%
 P value .614 NA .164 .172 .014 <.001 <.001
Note.—No significant difference (P = .556, Kruskal-Wallis) was identified among the four groups for rCBV values obtained with an interval of 1 second. Range indicates the overestimation or underestimation compared with the reference. Values in boldface indicate the temporal sampling interval thresholds beyond which rCBV values were significantly overestimated.
* Reference for Wilcoxon (Mann-Whitney) tests performed in each group. NA indicates not applicable.