TABLE 1:

FA values in three patients with PBD and age-matched control subjects

FA values × 10⁻³		12 Months					16 Months					80 Months
		Patient		Control		Diff.	Patient		Control		Diff.	Patient		Control		Diff.
		Mean (SD)	N	Mean (SD)	N	Diff.	Mean (SD)	N	Mean (SD)	N	Diff.	Mean (SD)	N	Mean (SD)	N	Diff.
White matter lateral to cerebellar	R	293 (45)	24	282 (36)	35	12	308 (46)	26	424 (47)	28	−116^‡	471 (66)	40	559 (74)	73	−88^‡
dentate nucleus	L	324 (43)	33	358 (68)	31	−34^*	303 (43)	29	410 (72)	31	−107^‡	461 (66)	57	490 (90)	56	−29^*
Cerebellar peduncle	R	660 (46)	12	814 (48)	12	−153^‡	753 (46)	12	788 (66)	12	−35	812 (59)	12	872 (42)	12	−60^†
	L	751 (80)	12	882 (26)	12	−130^‡	713 (67)	12	800 (48)	12	−86^†	595 (39)	12	849 (70)	12	−254^‡
Cerebral peduncle	R	526 (106)	39	677 (79)	15	−151^‡	584 (96)	46	608 (128)	35	−24	515 (90)	37	722 (125)	76	−207^‡
	L	591 (65)	26	585 (93)	34	6	608 (129)	37	642 (86)	34	−34	552 (77)	49	727 (84)	50	−175^‡
Optic radiation	R	364 (35)	12	562 (32)	12	−198^‡	507 (50)	12	599 (27)	12	−92^‡	605 (32)	12	625 (51)	12	−20
	L	455 (45)	12	520 (58)	12	−65^†	487 (27)	12	639 (74)	12	−152^‡	505 (65)	12	740 (93)	12	−235^‡
Genu of internal capsule	R	539 (32)	12	637 (79)	12	−98^‡	611 (37)	12	604 (41)	12	7	544 (31)	12	777 (53)	12	−233^‡
	L	561 (15)	12	582 (44)	12	−21	630 (39)	12	652 (69)	12	−22	658 (44)	12	809 (54)	12	−151^‡
Posterior limb of internal capsule	R	564 (99)	83	666 (97)	66	−102^‡	634 (144)	111	671 (117)	69	−37	613 (85)	124	734 (81)	79	−121^‡
	L	572 (88)	92	657 (79)	58	−85^‡	676 (101)	114	686 (75)	76	−10	663 (83)	107	747 (81)	98	−84^‡
Anterior limb of internal capsule	R	493 (75)	48	511 (87)	30	−18	476 (95)	57	547 (85)	38	−71^‡	487 (81)	42	676 (125)	39	−189^‡
	L	508 (113)	48	575 (68)	18	−67^*	508 (86)	62	599 (101)	33	−91^‡	556 (114)	79	594 (107)	41	−38
Genu of corpus callosum		599 (72)	12	732 (60)	12	−133^‡	544 (46)	12	908 (58)	12	−364^‡	532 (88)	12	779 (101)	12	−247^‡
Splenium of corpus callosum		532 (57)	12	523 (77)	12	9	695 (26)	12	893 (32)	12	−198^‡	618 (57)	12	608 (104)	12	10
Parietal corona radiata	R	207 (33)	51	247 (75)	51	−40^‡	237 (54)	51	301 (54)	51	−64^‡	240 (41)	51	270 (89)	51	−30^*
	L	162 (54)	51	199 (77)	51	−37^†	170 (41)	51	280 (57)	51	−110^‡	245 (59)	51	379 (77)	51	−134^‡
Frontal corona radiata	R	214 (31)	51	227 (54)	51	−13	232 (42)	51	327 (52)	51	−95^‡	362 (97)	51	423 (79)	51	−61^‡
	L	184 (71)	51	221 (78)	51	−37^*	252 (64)	51	249 (84)	51	3	339 (101)	51	403 (120)	51	−64^†
Centrum semiovale	R	317 (28)	51	427 (109)	51	−110^‡	432 (80)	51	465 (62)	51	−33^*	446 (150)	51	559 (76)	51	−113^‡
	L	318 (27)	51	407 (77)	51	−89^‡	388 (54)	51	526 (82)	51	−138^‡	442 (158)	51	507 (76)	51	−65^†

Note.—N indicates number of pixels per region of interest; significance determined with t test:
* P < .05;
† P < .01;
‡ P < .001.