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TABLE 2: 
Comparing two methods of measuring brain parenchymal fraction and their association with clinical and MR imaging variables in 52 patients with multiple sclerosis
SemiautomatedAutomated
2D3D2D3D
Third ventricular widthr = −.82, P < .001r = −.79, P < .001NRr = −.81, P < .001
Bicaudate ratior = −.74, P < .001r = −.74, P < .001NRr = −.74, P < .001
T1 hypointense lesion volumer = −.38, P = .006r = −.44, P = .001NRr = −.48, P < .001
FLAIR hyperintense lesion volumer = −.24, P = .09r = −.35, P = .01NRr = −.44, P = .001
EDSSr = −.44, P < .001r = −.47, P < .001NRr = −.33, P = .008
Disease durationr = −.50, P < .001r = −.39, P = .002NRr = −.53, P < .001