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Subject demographics, CAG repeat size, and test scores
Measure Participants
Far Close Control
Age (years)^* 33.0 (5.0) 41.1 (5.9) 38.0 (6.1)
Education (years) 14.6 (2.4) 14.1 (1.7) 14.9 (1.9)
Sex (M/F) (2/5) (4/3) (2/5)
CAG repeat size^† 41.3 (2.1) 44.2 (2.5) NA
Estimated years to symptom onset^‡ 24.6 (7.9) 8.6 (2.5) NA
UHDRS motor score 0.7 (1.0) 1.4 (0.9) NA
UHDRS verbal fluency 39.9 (11.7) 32.9 (8.7) 39.4 (6.4)
UHDRS symbol-digit 57.3 (10.0) 44.9 (8.8) 52.4 (10.9)
UHDRS stroop interference 50.9 (13.1) 37.1 (12.2) 44.0 (7.5)
Note.—NA indicates not applicable; UHDRS, Unified HD Rating Scale. Data are the mean (standard deviation).
* Close participants were significantly older than far participants (P < .05).
† Close participants had a significantly longer CAG repeat size than that of far participants (P < .05).
‡ In the close group, onset was predicted significantly earlier than in the far group (P < .001).