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TABLE 1: Clinical, MR, and fractional anisotropy data in nine medulloblastoma survivors
Patient (No.) Age (y) Age (y) at Treatment Interval (y) Total CRT Dose (Gy) Chemo WM VI FA ▵ (%) Postoperative Complications Deterioration in School Performance
1 19 13 6 54 babyPOG 0 0.31 19.2 None Moderate
2 16 14 2 54.6 CCV 0 0.22 21.9 None Moderate
3 13 12 1 50.4 CCV 0 0.27 9.9 None Mild
4 13 7 6 54 babyPOG 0 0.24 11.6 Cerebellar mutism Moderate
5 10 4 6 54 babyPOG 3 0.33 46.2 Hydrocephalus, shunt infection Severe
6 9 3 6 54 babyPOG 1 0.31 15.8 None Moderate
7 7 5 2 50.4 babyPOG 0 0.25 21.1 None Moderate
8 7 5 2 54 CCV 0 0.24 4 Bleeding during surgery Mild
9 3 3 1 50.4 babyPOG 2 0.30 18.2 Cerebellar mutism Moderate^*
Note.—CRT signifies cranial radiation therapy; Chemo, chemotherapy regimen; WM, white matter grade determined by MR imaging (4-point scale [see Methods]); VI, ventricular index (maximum width of the frontal horns divided by the maximum internal skull diameter); FA ▵ (%), percentage of reduction in the supratentorial white matter fractional anisotropy of patients versus controls.
* Delayed developmental milestones.