TABLE 2:

Fractional anisotropy index

FA	Patient 1				Patient 2				Patient 3				Control Participant		Mean −1 SD	Mean −2 SD
FA	Mean	SD	ROI	T2	Mean	SD	ROI	T2	Mean	SD	ROI	T2	Mean	SD	Mean −1 SD	Mean −2 SD
PLIC-l	0.76	0.05	9	0	0.68	0.06	9	1	0.73	0.10	9	1	0.76	0.02	0.75	0.73
PLIC-r	0.72	0.06	8	0	0.65	0.06	9	1	0.75	0.04	9	1
CSO-l	0.56	0.08	29	0	0.32	0.11	36	1	0.50	0.06	51	0	0.54	0.05	0.48	0.43
CSO-r	0.57	0.07	25	0	0.32	0.13	38	1	0.48	0.07	52	0
FWM-l	0.36	0.10	62	0	0.37	0.10	80	0	0.33	0.09	100	0	0.38	0.04	0.34	0.31
FWM-r	0.37	0.10	80	0	0.38	0.09	103	0	0.38	0.11	105	0
PWM-l	0.33	0.09	85	0	0.11	0.06	160	1	0.39	0.07	112	0	0.40	0.02	0.38	0.35
PWM-r	0.31	0.11	75	0	0.11	0.05	206	1	0.40	0.08	158	0
TWM-l	0.44	0.08	93	0	0.13	0.04	91	1	0.40	0.07	100	0	0.47	0.03	0.43	0.40
TWM-r	0.42	0.10	113	0	0.12	0.03	94	1	0.41	0.08	130	0
OWM-l	0.47	0.10	90	0	0.11	0.07	77	1	0.46	0.10	69	0	0.46	0.04	0.42	0.38
OWM-r	0.44	0.11	71	0	0.10	0.05	85	1	0.44	0.13	96	0
GCC-l	0.66	0.13	24	0	0.68	0.12	22	0	0.69	0.12	21	0	0.72	0.07	0.66	0.59
GCC-r	0.75	0.10	18	0	0.64	0.13	20	0	0.67	0.10	26	0
SCC-l	0.72	0.10	28	0	0.21	0.03	16	1	0.79	0.15	27	0	0.78	0.05	0.73	0.68
SCC-r	0.76	0.06	20	0	0.20	0.02	18	1	0.81	0.08	19	0
ALIC-l	0.53	0.13	11	0	0.49	0.09	13	0	0.38	0.06	16	1	0.54	0.06	0.48	0.43
ALIC-r	0.62	0.08	9	0	0.60	0.12	8	0	0.43	0.04	12	1

Note.—FA indicates fractional anisotropy; ROI, region of interest; T2, T2 value on T2-weighted MR images; -l, on the left side; -r, on the right side; PLIC, posterior limb of the internal capsule; CSO, centrum semiovale; FWM, frontal white matter; PWM, parietal white matter; TWM, temporal white matter; OWM, occipital white matter; GCC, genu corporis callosi; SCC, splenium corporis callosi; ALIC, anterior limb of the internal capsule. Fractional anisotropy values for three patients with X-linked adrenoleukodystrophy, indicated as mean values and intra-region of interest SDs (inter-pixel SDs), are compared with those of seven age-matched normal control participants, indicated as mean values and inter-region of interest SDs. Values shown on light gray background are between 1 and 2 SDs of the mean, and values shown on dark gray background are >2 SDs of the mean, compared with values for normal control participants. T2 values are either 0 for T2-weighted images without evidence of demyelination in the specific region or 1 for T2-weighted images with evidence of demyelination.