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TABLE 1: 
Clinical and radiologic findings in the two study groups
Ischemic Leukoaraiosis (n = 50)CADASIL (n = 19)
Clinical characteristics
 Age (yr ± SD)69.8 ± 9.8 (range, 47–86)47.3 ± 12.2 (range, 21–69)
 Males32 (64%)8 (42%)
 Hypertension40 (80%)1 (5%)
 Diabetes mellitus6 (12%)None
 Anti-platelet therapy46 (92%)15 (79%)
 Anti-coagulant therapyNone2 (10%)
Global cognitive function
 MMSE score 28–3025 (50%)16 (84%)
 MMSE score 24–2714 (28%)3 (16%)
 MMSE score <247 (14%)None
MR imaging findings
 Confluent changes (score of 3 on Fazekas scale)43 (86%)17 (90%)
  • Note.—CADASIL indicates cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; MMSE, Mini-Mental State Examination.