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TABLE 1: Summary of clinical features in five patients with delayed encephalopathy of CO intoxication
Patient/Age, y/Sex^* Initial Manifestations of Acute CO Intoxication Lucid Interval, wk Major Clinical Findings of Delayed Encephalopathy
1/54/F Coma with multiple burn injury 3 Short-term memory loss, confabulation; much improved at 7-mo follow-up
2/71/M Sudden decrease of verbal output, free voiding 1 Aphasia, gait disturbance; much improved at 5-mo follow-up
3/63/M Abnormal repetitive behavior, progressive abulia 3 Abulia, akinetic mutism; much improved at 8-mo follow-up
4/65/F Coma, decrease of verbal output and cognitive dysfunction 4 Urinary/fecal incontinence, short-stepped gait; persistent clinical symptoms at 6-mo follow-up
5/63/F Coma, free voiding, and defecation 4 Abulia, bradykinesia, free voiding; much improved at 5-mo follow-up
* In all patients except patient 4, the cause of their exposure to CO gas was a gas leakage from an under-the-floor home heating system. Patient 4 was exposed to exhaust gas from a car.