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TABLE 2: Metabolite ratios
Individual Metabolite Levels Relative to Gray Matter Metabolite Ratios
Cho Cr NAA NAA/Cho NAA/Cr Cho/Cr
A. Frontal white matter 
Patient 1 1.17 1.19 0.84 1.16 1.63 1.41
Patient 2 1.28 1.01 1.02 1.62 2.63 1.63
Patient 3 1.68 0.95 0.87 1.27 2.32 1.83
Control subject 1 1.64 1.00 0.81 1.09 2.17 2.00
Control subject 2 1.51 0.92 0.94 1.26 2.57 2.03
Control subject 3 1.14 0.61 0.85 1.89 4.17 2.21
B. Centrum semiovale 
Patient 1 1.38 1.11 0.74 0.87 1.55 1.79
Patient 2 1.28 0.95 0.89 1.42 2.43 1.71
Patient 3 1.61 1.02 0.96 1.46 2.38 1.63
Control subject 1 1.35 0.81 0.82 1.34 2.71 2.03
Control subject 2 1.38 0.85 0.99 1.46 2.90 1.99
Control subject 3 1.55 0.85 0.99 1.61 3.46 2.15
C: Parietal white matter 
Patient 1 1.31 1.03 0.61 0.76 1.37 1.81
Patient 2 1.13 0.97 0.93 1.69 2.50 1.48
Patient 3 1.65 1.03 0.81 1.20 1.98 1.66
Control subject 1 1.42 0.92 0.84 1.29 2.42 1.87
Control subject 2 1.42 0.84 0.96 1.37 2.84 2.07
Control subject 3 1.45 0.66 0.84 1.46 3.80 2.60
D: Parieto-occipital gray matter^* 
Patient 1 NA NA NA 1.61 2.31 1.43
Patient 2 NA NA NA 2.03 2.60 1.28
Patient 3 NA NA NA 2.44 2.52 1.04
Control subject 1 NA NA NA 2.19 2.67 1.22
Control subject 2 NA NA NA 2.03 2.50 1.23
Control subject 3 NA NA NA 2.52 2.99 1.18
Note.—Patient 1 was aged 2 years 5 months; patient 2, 3 years, 8 months; patient 3, 7 years, 6 months; control subject 1, 1 year, 9 months; control subject 2, 3 years, 2 months; and control subject 3, 7 years, 0 months.
* NA indicates not applicable.