Diseases involving bilateral middle cerebellar peduncles

Diagnosis (no.)	Age/sex	Pontine Lesions	Cbll Lesions	Other Lesions
Degenerative diseases (11)
sOPCA (8)	47, 50, 53, 55/M,61, 68, 71, 72/F	Cross sign, atrophy	Atrophy	Atrophy of basal ganglia with linear hyperintensity at lateral margins (3)
SCA2 (1)	42/M	Cross sign, atrophy	Atrophy	(-)
SCA6 (1)	48/F	Cross sign, atrophy	Atrophy	(-)
Shy-Drager synd (1)	57/M	Linear lesion on midline	(-)	(-)
Metabolic diseases (6)
Adrenoleukodystrophy (2)	4, 38/M	Lesions along pyramidal tracts (1), heterogeneous lesions (1),	WML (2)	Large symmetrical parieto-occipial WML (1), lesions along pyramidal tracts (1)
Wilson disease (2)	24/M, 34/F	Several small lesions (2), atrophy (1)	Mild atrophy (1)	Midbrain (tegmentum) and basal ggl lesions (2) and thalamic lesions (1)
Alcoholic liver cirrhosis (1)	51/M	(-)	Mild atrophy	T1 hyperintensity at globi pallidi
Hypoglycemic coma (1)	52/F	Lesions along pyramidal tracts on DWI	(-)	Hyperintensity lesions along pyramidal tracts on T2WI and DWI
Neoplasms (3)
Diffuse infiltrating ML (1)	55/F	Heterogeneous lesions, enlargement	Diffuse WML	Whole corpus callosum and diffuse cbr WML
Brain stem glioma (1)	74/M	Ring-enhancement, enlargement	(-)	Tumor extension into medulla oblongata and midbrain
Meningeal carcinomatosis (1)	77/F	Multiple lacunar infarcts	Enhancement in fissures	Leptomeningeal enhancement, multiple lacunar infarction, mild hydrocephalus
Cerebrovascular disease, hypertensive and its related encephalopathies (3)
AICA infarction (1)	57/M	Lacunar infarcts	Infarction in AICA distribution	Multiple lacunar infarction
Hypertensive encephalopathy (1)	51/F	Heterogeneous lesion, enlargement	Diffuse WML, swelling	Midbrain, basal ganglia, thalamus, bilateral hippocampus, periventricular WML
Cyclosporin-A encephalopathy (1)	16/F	A few punctate lesions	Diffuse swelling	Small parietal WML
Inflammatory & demyelinating diseases (4)
Multiple sclerosis (1)	17/F	Small tegmental lesions	Mild atrophy	Small lesions in corpus callosum, small oval periventricular WML
ADEM (1)	38/M	Heterogeneous lesions	(-)	Multiple subcortical WML
Behcet disease (1)	66/F	Subtle heterogeneous lesions	(-)	Non-specific punctate WML
HIV encephalopathy (1)	31/M	Diffuse hyperintensity	(-)	Frontal WML, mild brain atropohy
Total (27)	mean age, 48.5 y

Note.—ADEM, acute disseminated encephalomyelitis; cbll, cerebellar; cbr, cerebral; DWI, diffusion-weighted imaging; ggl, ganglia; HIV, human immunodeficiency virus; ML, malignant lymphoma; SCA, spinocerebellar ataxia; sOPCA, sporadic olivopontocerebellar atrophy; T2WI, T2-weighted imaging; WML, white matter lesions.