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Table 2: Regions of gray and white matter volume loss in patients with ALS compared with HCs
Cluster Size^{^a} BA Regions MNI Coordinates (mm) TValues
X Y Z
Gray matter volume loss 
    54 BA 39 R angular gyrus 33 −57 45 4.28
    29 BA 4 L precentral gyrus −45 −6 30 4.02
    65 BA 46 L middle frontal gyrus −24 40 19 4.00
    46 BA 4 R precentral gyrus 30 −16 41 3.72
BA 4 R precentral gyrus 38 −10 43 3.43
    22 BA 48 R rolandic operculum 56 2 14 3.62
White matter volume loss 
    51 L superior frontal lobe −19 53 28 4.14
    240 R supplementary motor area 8 −26 54 3.92
R precentral region 17 −15 70 3.61
R precentral region 16 −20 59 3.57
    47 L supplementary motor area −3 −21 56 3.80
    25 L inferior temporal area −40 −28 −13 3.59
a The number of voxels. P< .001 uncorrected within at least 20 contiguous voxels.

Cluster Size^{^a}	BA	Regions	MNI Coordinates (mm)			TValues
Cluster Size^{^a}	BA	Regions	X	Y	Z	TValues
Gray matter volume loss
54	BA 39	R angular gyrus	33	−57	45	4.28
29	BA 4	L precentral gyrus	−45	−6	30	4.02
65	BA 46	L middle frontal gyrus	−24	40	19	4.00
46	BA 4	R precentral gyrus	30	−16	41	3.72
	BA 4	R precentral gyrus	38	−10	43	3.43
22	BA 48	R rolandic operculum	56	2	14	3.62
White matter volume loss
51		L superior frontal lobe	−19	53	28	4.14
240		R supplementary motor area	8	−26	54	3.92
		R precentral region	17	−15	70	3.61
		R precentral region	16	−20	59	3.57
47		L supplementary motor area	−3	−21	56	3.80
25		L inferior temporal area	−40	−28	−13	3.59