Patient demographics and imaging findings

No.	Age (yr)/Sex	Symptoms	Areas of Involvement	Biopsy Sites	CNS Imaging Findings
1	37/F	Diffuse bone pain,extremity numbness,gait instability,diabetes insipidus	Pituitary/hypothalamus,brain stem, calvarium/skull base, spine, appendicular skeleton, lungs	Brain stem lesion, lung, left clavicle	Enlarged pituitary stalk, FLAIR hyperintensity hypothalamus, FLAIR hyperintensity/enhancement pons, lytic calvarial and mandibular lesions, spinal and sacral lesions (Fig 5)
2	69/M	Hydro-nephrosis	No CNS disease demonstrated, retroperitoneum, interstitial lung disease	Retroperitoneum, lung	NA
3	47/M	Hydro-nephrosis, diabetes insipidus	Pituitary, mediastinum, lung, retroperitoneum, appendicular skeleton	Renal	Enlarged pituitary stalk
4	66/M	Diabetes insipidus	Brain stem, sinuses, orbit, appendicular skeleton, retroperitoneum, renal	Sphenoid sinus, orbit, retroperitoneum, renal	T2 hyperintensity pons, sphenoid sinus mass, intraconal orbital mass, enlarged pituitary stalk
5	69/M	Diabetes insipidus	No CNS disease demonstrated, appendicular skeleton, retroperitoneum, chest	Femur, lung	NA
6	62/M	Numbness head and neck, gait instability	Brain stem, appendicular skeleton, perinephric infiltration	Tibia	FLAIR hyperintensity/enhancement pons and cerebellum (Fig 3)
7	61/F	Leg pain	No CNS disease demonstrated, appendicular skeleton, skin	Extremity soft tissues, tibia	NA
8	49/M	Fatigue, diabetes insipidus	Orbits, sella/cavernous sinuses, appendicular skeleton, retroperitoneum	Orbit	Intra-/extraonal orbital mass (Fig 4), sellar/cavernous sinus mass (Fig 4), enlarged pituitary stalk
9	60/M	Ascites	Calvarium/skull base, mesentery, retroperitoneum	Bone marrow	Enhancing calvarial foci
10	48/F	Fatigue, mental status change	Intracranial extra-axial, cerebellum, orbit, skull base	NA	IC extra-axial lesions (Fig 1), dentate nucleus hyperintensity, intraconal retrobulbar exophthalmos, sclerotic focus skull base
11	64/M	Abdominal pain, diabetes insipidus, extremity weakness	Intracranial, intra-axial, brain stem, cerebellum, orbit, mediastinum, retroperitoneum, appendicular skeleton	Pararenal	Ependymal enhancement to lentiform nucleus (Fig 2), FLAIR hyperintensity/enhancement, pons and cerebellum, intraconal orbital mass

Note:—NA indicates not applicable; IC, intracranial.