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Table 2: Mean subcortical nuclei volume in cubic centimeters per diagnosis: MANCOVA analysis applied for estimating group differences^a
Anatomy A B C MANCOVA Post Hoc Comparison Cohen D
Control Child B Child C
Mean Volume (SD) (cm³) F P Value A vs B B vs C A vs C
L accumbens 0.39 (0.11) 0.35 (0.09) 0.30 (0.07) 2.64 .08 0.42 0.69 1.01
L amygdala 1.12 (0.19) 1.02 (0.20) 0.94 (0.23) 3.12 .05^b A > C; A, B (NS); B, C (NS) 0.51 0.39 0.87
L caudate 3.09 (0.35) 2.92 (0.48) 2.70 (0.41) 3.53 .04^b A > C; A, B (NS); B, C (NS) 0.39 0.49 1.01
L hippocampus 3.61 (0.44) 3.66 (0.41) 3.51 (0.72) 0.11 .90 −0.13 0.27 0.17
L pallidus 1.78 (0.28) 1.60 (0.48) 1.57 (0.56) 1.21 .31 0.47 0.04 0.47
L putamen 4.77 (0.54) 4.33 (0.87) 3.81 (0.75) 7.17 <.01^b A > B; A > C; B, C (NS) 0.60 0.64 1.47
L thalamus 7.24 (0.62) 7.25 (0.56) 6.84 (0.63) 0.78 .46 −0.02 0.69 0.64
R accumbens 0.29 (0.09) 0.26 (0.12) 0.22 (0.09) 1.03 .36 0.30 0.32 0.71
R amygdala 1.08 (0.22) 0.95 (0.25) 0.93 (0.20) 2.59 .09 0.53 0.10 0.70
R caudate 3.22 (0.40) 3.20 (0.52) 2.97 (0.42) 0.76 .47 0.04 0.49 0.61
R hippocampus 3.77 (0.53) 3.85 (0.58) 3.75 (0.38) 0.06 .94 −0.14 0.20 0.04
R pallidus 1.78 (0.30) 1.63 (0.44) 1.56 (0.46) 1.13 .33 0.38 0.17 0.57
R putamen 4.58 (0.51) 4.24 (0.81) 3.96 (0.73) 3.71 .03^b A > B; A > C; B, C (NS) 0.51 0.37 0.99
R thalamus 6.99 (0.61) 7.07 (0.54) 6.74 (0.70) 0.12 .89 −0.14 0.53 0.38
Note:—L indicates left; R, right; NS, no significance.

↵a Adjusted for age, sex, education years, and TIV.

↵b Indicates threshold for statistical significance was set at P < 0.05.