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Table 1: Baseline and follow-up MTR data, brain volume loss, and MMSE score
Controls AD Baseline AD Month 6 AD Month 12
n 19 28 27 18
Sex (M/F) 8/11 14/14 14/13 8/10
Age 73.3 (3.2) 76.5 (5.8) 76.5 (5.9) 76.1 (5.8)
Global MTR 
    Histogram peak position [%] 67.21 (0.68) 66.51 (1.0)^{^a} 65.77 (0.90)^{^b} 65.46 (1.20)^{^b}
    Histogram peak height [a.u.] 0.591 (0.04) 0.554 (0.04)^{^a} 0.515 (0.07)^{^b} 0.501 (0.06)^{^b}
    Mean histogram MTR [%] 55.26 (1.30) 53.55 (1.50)^{^a} 51.63 (1.37)^{^b} 50.89 (1.45)^{^b}
Regional MTR 
    Hippocampus MTR [%] 63.68 (1.51) 62.51 (1.21)^{^a} 61.04 (1.42)^{^b} 60.48 (1.15)^{^b}
    Caudate nucleus MTR [%] 57.51 (1.01) 57.15 (1.24) 55.52 (2.23)^{^b} 54.7 (2.06)^{^b}
    Thalamus MTR [%] 62.51 (1.47) 63.33 (1.52) 61.78 (1.99)^{^b} 61.35 (2.35)^{^b}
    Putamen MTR [%] 57.74 (1.13) 58.04 (1.49) 58.12 (1.21) 57.59 (1.47)^{^b}
Brain volume loss [%] NA NA 1.04 (1.68) 2.22 (1.87)
Hippocampal volume loss [%] NA NA 1.77 (2.99) 2.86 (3.62)
MMSE 27.6 (0.8) 18.9 (2.8) 18.8 (4.8) 18.6 (4.3)
Note:—For the regional MTR analysis, values from both hemispheres were averaged; a.u. indicates arbitrary unit(s).
↵a Significant difference between AD patients and controls.
↵b Significant difference from baseline.