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Table 2: Correlation between HDWM DA or callosal parameters and cognitive scores evaluated with multiple regression analyses^a
MMSE FAB VFT WMSR
HDWM DA 
    FA25 0.76^b 0.79^b 0.64^c 0.72^b
    Mean FA 0.71^b 0.73^b 0.56^d 0.66^c
    MD25 −0.99^b −0.89^b −0.59^e −0.83^b
    Mean MD −0.91^b −0.78^b −0.52^f −0.86^b
Callosal mean FA 0.80^b 0.85^b 0.70^b 0.73^g
Callosal mean MD −0.74^b −0.66^b −0.59^{^g,^h} −0.82^b
Callosal volume 0.74^b 0.8^b 0.72^b 0.63^f


↵a Figures are standardized regression coefficients between each of the HDWM DA or callosal parameters and each of the cognitive scores, adjusted for age, sex, WML volume, and white matter volume.


↵b Significant after Bonferroni correction (P < .05/28 = .0018).


↵c P = .002.


↵d P = .006.


↵e P = .02.


↵f P = .03.


↵g P = .003.


↵h White matter volume showed a weak contribution to the correlation between callosal MD and VFT (standard regression coefficient, 0.43; P =.046).

	MMSE	FAB	VFT	WMSR
HDWM DA
FA25	0.76^b	0.79^b	0.64^c	0.72^b
Mean FA	0.71^b	0.73^b	0.56^d	0.66^c
MD25	−0.99^b	−0.89^b	−0.59^e	−0.83^b
Mean MD	−0.91^b	−0.78^b	−0.52^f	−0.86^b
Callosal mean FA	0.80^b	0.85^b	0.70^b	0.73^g
Callosal mean MD	−0.74^b	−0.66^b	−0.59^{^g,^h}	−0.82^b
Callosal volume	0.74^b	0.8^b	0.72^b	0.63^f