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Table 1: Techniques for reducing T1 leakage effects
Category Technique Examples
Image acquisition  Low flip angle, long TE, double-echo T2*-weighted Knopp et al,11 Cha et al38 Vonken et al,27 Uematsu et al28
Contrast agent Use of loading doses^a Donahue et al,3 Schmainda et al,21 Simonsen et al35
Intravascular agents (eg, ferumoxytol) Gahramanov et al20
Postprocessing Linear fit + leakage model^a Weisskoff et al,31 Schmainda et al21 Boxerman et al22
γ-Variate fit Law et al4
Limited integration Wong et al30
Baseline subtraction Wetzel et al29
↵a Designates the 2 techniques investigated in this article.

Category	Technique	Examples
Image acquisition	Low flip angle, long TE, double-echo T2*-weighted	Knopp et al,11 Cha et al38 Vonken et al,27 Uematsu et al28
Contrast agent	Use of loading doses^a	Donahue et al,3 Schmainda et al,21 Simonsen et al35
	Intravascular agents (eg, ferumoxytol)	Gahramanov et al20
Postprocessing	Linear fit + leakage model^a	Weisskoff et al,31 Schmainda et al21 Boxerman et al22
	γ-Variate fit	Law et al4
	Limited integration	Wong et al30
	Baseline subtraction	Wetzel et al29