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Table 4: Baseline MRI and clinical markers of patients with and without MSFC progression
MSFC Nonprogression (Mean) MSFC Progression (Mean) P
No. of patients 25 13 
ADC histogram markers^a
    Mean (10⁻⁶ m²/s) 0.956 ± 0.021 0.976 ± 0.039 .042
    Variance (10⁻⁶ m²/s) 0.088 ± 0.008 0.092 ± 0.008 n.s.
    Skew 1.035 ± 0.116 0.951 ± 0.193 n.s.
    Peak height (10⁻³) 2.662 ± 0.241 2.539 ± 0.282 n.s.
    Peak position (10⁻⁶ m²/s) 0.758 ± 0.017 0.768 ± 0.018 n.s.
BPF 0.828 ± 0.040 0.783 ± 0.027 .001^b
WMLL_perc (%) 3.365 ± 1.673 4.435 ± 2.228 n.s.
Clinical variables^c
    Age 36.9 ± 9.2 39.5 ± 11.0 n.s.
    Disease duration 6.6 ± 6.6 7.5 ± 7.0 n.s.
    Baseline MSFC 0.53 ± 0.46 0.59 ± 0.33 n.s.
Note:—n.s. indicates not significant.


↵a Analysis of covariance with 2-level group factor and age as covariate for MRI variables.


↵b P value lower than Bonferroni-corrected .05/7 ∼ .007.


↵c Two-sided t tests for comparison of clinical variables.