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Table 2: Change of neurologic scores during a median of 12 months
Score No. Baseline Follow-Up^a P Value^b Split Threshold^c Progression Nonprogression
EDSS (median) (range) 44 2.0 (0–5.5) 2.0 (0–5.5) 0.950 ≥0.5^c 9 35
MSFC (mean) (SD) 38 0.550 (0.415) 0.549 (0.475) 0.969 <−0.047 13 25
TWT (mean) (SD)^d 39 −0.431 (0.082) −0.412 (0.098) 0.105 >0.013 16 23
9-HPT (mean) (SD)^e 40 0.780 (0.735) 0.736 (0.837) 0.382 <−0.113 15 25
PASAT (mean)^f 39 0.460 (0.693) 0.531 (0.800) 0.414 <−0.101 8 31


↵a Annualized values for MSFC, raw values for EDSS (for details see “Materials and Methods”).


↵b Two-sided Wilcoxon signed rank test (EDSS) and paired Studentt test (MSFC, annualized follow-up values), respectively.


↵c See “Materials and Methods” section for details on threshold definition.


↵d TWT.


↵e 9-HPT.


↵f PASAT.