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Table 2: 
Overview of main POC devices used to measure ACT


ManufacturerDeviceACT TestReagentDetection MethodRemarks
International TechnidyneHemochron Jr. Signature, Signature+, and Signature EliteACT and ACT-LRKaolinOpticalResult is automatically converted to a reference Celite-ACT value
Hemochron Response3 different ACT tests: FTCA510, KACT, P214Celite in glass tube (high heparin levels), kaolin in glass tube (if aprotinin is present), glass beads in plastic tube (low heparin levels)MechanicalOther capabilities: RxDx heparin/protamine dosing system
Hemochron Jr. HemonoxHemonox-CTProprietary lipidated recombinant–rabbit-brain tissue factorMechanicalDesigned specifically to monitor LMWH
MedtronicHMS PLUSACT-HRCeliteMechanicalOther capabilities: heparin dose response and heparin protamine titration
ACT PLUSACT-LRCeliteMechanical
SiencoSonoclotAprotinin-insensitive ACT (SaiACT)Celite + clayMechanical
Abbott Laboratoriesi-STATCelite-ACT, kaolin-ACTCelite kaolinElectrochemical
Instrumentation LaboratoryGEM PCLACT, ACT-LRKaolin (for ACT), Celite + silica (for ACT-LR)Optical
Helena LaboratoriesCascadeCelite-ACTCelitePhotomechanicalCan also perform Enox and LMWH tests
Actalyke XL, Actalyke Mini IICelite-ACT, kaolin-ACT, glass-ACT, MAX-ACTCelite, kaolin, glass, or a cocktail of Celite, kaolin and glass2-Point, electromechanicalLinear correlation with heparin level ≤10 U/mL for XL model and 6 U/mL for Mini II model tubes can be used in Hemochron system
  • 

    Note:—LR = low range; HR = high range.