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Table 1: Overview of some important facts on anticoagulation and ACT
ACT and Anticoagulation Facts


Celite, kaolin, and glass are activators used to measure ACT that yield different results

Celite-ACT is significantly longer than kaolin ACT

ACT values from a particular device are reproducible and correlate with anti-Xa values

ACT is device-specific even if the activator used is the same

ACT following administration of heparin varies based on heparin-dependent (heparin responsiveness/resistance) and heparin-independent (hemodilution, hypothermia, platelet count, race, and so forth) factors

LMWH anticoagulation can be monitored by ACT

Hemonox-CT is a more specific POC test for LMWH

Concomitant use of abciximab increases ACT; eptifibatide leads to less marked changes in ACT

Concomitant aprotinin administration affects Celite-ACT more than kaolin-ACT

Heparin concentrations are divided into high (>1 U/mL) and low (<1 U/mL)

Kaolin-based ACT is less accurate in low-intensity anticoagulation

Glass beads in a plastic tube are more effective in moderate heparin concentrations

Hemochron produces lower ACT values than the Automated Coagulation Timer System (previously HemoTec)

The corresponding anti-Xa values are needed to establish a therapeutic ACT range for a particular device

Institutions should establish their individual therapeutic ACT ranges