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Table 1: Volumetric regional gray matter differences in patients with clinically isolated syndrome compared with patients with early relapsing-remitting multiple sclerosis^a
CIS (n = 212) (mean) (SD) Early RRMS (n = 177) (mean) (SD) Volumetric Differences between CIS and Early RRMS^b
% Difference SED P Value Adjusted P Value
NCV 614.24 (33.11) 609.41 (38.69) −0.79 3.64 .186 .532
Total SDGMV 63.24 (3.93) 61.9 (5.12) −2.12 0.46 .004 .001
Caudate 9.33 (1.00) 8.96 (1.03) −3.97 0.1 <.0001 <.0001
Putamen 13.29 (1.04) 13.04 (1.32) −1.88 0.12 .040 .051
Globus pallidus 4.74 (0.36) 4.66 (0.93) −1.69 0.04 .022 .01
Thalamus 21.25 (1.50) 20.42 (1.97) −3.91 0.18 <.0001 <.0001
Hippocampus 9.83 (0.94) 10.02 (1.10) 1.93 0.1 .068 .251
Amygdala 3.52 (0.44) 3.56 (0.42) 1.14 0.04 .416 .523
Nucleus accumbens 1.3 (0.24) 1.27 (0.26) −2.31 0.03 .228 .213
Note:—SDGMV indicates subcortical deep gray matter volume; SED, standard error of difference.
↵a All volumes are reported in milliliters.
↵b Student t test and analysis of variance were used to assess volumetric differences between CIS and RRMS groups.