Table 3:

Spearman rank correlations between regional gray matter volumes and other MRI and clinical outcomes in patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis

	T2 LV r (P)	NBVr (P)	NLVVr (P)	EDSSr (P)	Disease Durationr (P)
CIS (n = 212)
NCV	−.102 (.140)	.936 (<.0001)^a	−.359 (<.0001)^a	−.149 (.033)	.035 (.614)
Total SDGMV	−.329 (<.0001)^a	.498 (<.0001)^a	−.178 (.009)^a	−.040 (.568)	−.126 (.069)
Caudate	−.263 (<.0001)^a	.430 (<.0001)^a	−.293 (<.0001)^a	−.137 (.051)	−.071 (.310)
Putamen	−.162 (.018)	.470 (<.0001)^a	−.114 (.098)	−.049 (.488)	−.128 (.065)
Globus pallidus	−.145 (.035)	.190 (<.005)^a	.176 (.010)	−.063 (.370)	−.082 (.239)
Thalamus	−.328 (<.0001)^a	.465 (<.0001)^a	−.264 (<.0001)^a	−.024 (.734)	−.033 (.634)
Hippocampus	−.218 (.001)^a	.162 (.018)	−.080 (.244)	.050 (.476)	−.095 (.171)
Amygdala	−.132 (.054)	.074 (.287)	.092 (.181)	.059 (.403)	−.194 (.005)^a
Nucleus accumbens	−.132 (.055)	.370 (<.0001)^a	−.141 (.041)	.065 (.356)	−.111 (.110)
Early RRMS (n = 177)
NCV	−.420 (<.0001)^a	.954 (<.0001)^a	−.509 (<.0001)^a	−.204 (.006)^a	−.383 (<.0001)^a
Total SDGMV	−.613 (<.0001)^a	.698 (<.0001)^a	−.438 (<.0001)^a	−.184 (.014)	−.322 (<.0001)^a
Caudate	−.558 (<.0001)^a	.530 (<.0001)^a	−.315 (<.0001)^a	−.171 (.023)	−.282 (<.0001)^a
Putamen	−.520 (<.0001)^a	.629 (<.0001)^a	−.358 (<.0001)^a	−.125 (.098)	−.306 (<.0001)^a
Globus pallidus	−.408 (<.0001)^a	.342 (<.0001)^a	−.092 (.223)	−.070 (.351)	−.169 (.024)
Thalamus	−.619 (<.0001)^a	.721 (<.0001)^a	−.604 (<.0001)^a	−.204 (.007)^a	−.338 (<.0001)^a
Hippocampus	−.312 (<.0001)^a	.412 (<.0001)^a	−.140 (.063)	−.093 (.216)	−.173 (.021)
Amygdala	−.246 (.001)^a	.108 (.152)	−.017 (.818)	−.067 (.375)	−.124 (.100)
Nucleus accumbens	−.335 (<.0001)^a	.538 (<.0001)^a	−.388 (<.0001)^a	−.095 (.208)	−.164 (.029)

Note:—LV indicates lesion volume; SDGMV, subcortical deep gray matter volume.
↵a Significant P values (P < .01).