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Table 3: Multivariate predictors of lnWMHV in 201 patients with AIS
Predictors Estimate T Value P Value
Model 1^a F = 13.42 <.0001
    Age (yr) 0.03 6.34 <.0001^d
    Sex 0.07 0.45 .65
    SBP 0.01 2.24 .03^d
    HTN 0.12 0.68 .50
    Extracranial carotid stenosis 0.03 0.16 .87
Model 2^b F = 11.45 <.0001
    Age (yr) 0.03 6.19 <.0001^d
    Sex 0.11 0.66 .51
    SBP 0.01 2.43 .02^d
    HTN 0.14 0.79 .43
    Extracranial carotid stenosis 0.11 0.60 .55
    Intracranial arterial stenosis −0.12 −0.69 .49
Model 3^c F = 2.35 .10
    Intracranial arterial stenosis −0.01 −0.05 .96
    Extracranial carotid stenosis 0.42 2.06 .04^d


↵a Model includes all univariate predictors with P < 0.2. 


↵b Model includes all univariate predictors with P < 0.2 and intracranial arterial stenosis.


↵c Exploratory model of the effect of subtype of large-artery stenosis on white matter hyperintensity burden.


↵d Statistically significant.