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Table 2: Volumetric gray matter differences in patients with clinically isolated syndrome with low- and high-T2 lesion volume^a
CIS with T2-LV < 4.49 mL (n = 106) (mean) (SD)^b CIS with T2-LV > 4.49 mL (n = 106) (mean) (SD)^b % Difference SED P Value
NBV 1499 (67.1) 1487 (80.1) −0.8 6.5 .238
NLVV 35.3 (9.8) 40.3 (12.4) +14.2 0.5 .001
NCV 618.18 (30.7) 610.31 (35.1) −1.27 4.53 .084
Total SDGM 64.52 (3.65) 61.96 (3.79) −3.97 0.51 <.0001
Caudate 9.6 (0.91) 9.05 (1.01) −5.73 0.13 <.0001
Putamen 13.46 (0.94) 13.10 (1.1) −2.67 0.14 .010
Globus pallidus 4.8 (0.37) 4.68 (0.34) −2.50 0.04 .007
Thalamus 21.73 (1.36) 20.77 (1.47) −4.42 0.19 <.0001
Hippocampus 10.01 (0.97) 9.64 (0.87) −3.70 0.13 .004
Amygdala 3.59 (0.41) 3.45 (0.46) −3.90 0.06 .021
Nucleus accumbens 1.32 (0.22) 1.28 (0.26) −3.03 0.04 .204
Note:—SDGMV indicates subcortical deep gray matter volume; SED, standard error of difference; LV, lesion volume.
↵a All volumes are reported in milliliters.
↵b Student t test was used to assess volumetric differences between patients with CIS with T2 lesion volume <4.49 mL and those with CIS with >4.49 mL T2 lesion volume.