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Table 2: Summary of main regions exhibiting reduced anisotropy and increased diffusivity in patients with SCA compared with the control population
WM Tract Anisotropy Diffusivity
EAR FA MO RD MD
NL MG NL MG NL MG NL MG NL MG
Bilateral
    Corpus callosum (body) − + − + − + − + − +
    Corpus callosum (genu) − + − +, mostly posterior − +, mostly posterior − + − +
    Corpus callosum (splenium) − + − NS − − − + − +
    Centrum semiovale + + + + NS + − + − +
Unilateral
    Inferior fronto-occipital fasciculus (R) − NS − + − − − + − +
    SLF(R) − − − − − − NS + NS +
    SLF(L) − − − NS − − NS + NS +
Note:—+ indicates significant at the default confidence level (95%); −, not significant at this level; L, left; MG, patients with mild gliosis; NL, radiologically normal patients; NS, trend toward significance (detectable at reduced confidence level); R, right; SLF: superior longitudinal fasciculus.