Table 2:

Analysis of median percent change of tCho/NAA

Patient	Median % Change tCho/NAA Enhancing	Median % Change tCho/NAA Nonenhancing	Median % Change tCho/NAA Control	Median % Change tCho/NAA White Matter	Median % Change tCho/NAA Gray Matter	RANO Response Assessment²⁶
1	123.94	4.05	24.95	−12.89	−3.57	SD
2	−24.83	−8.94	33.59	−4.44	13.08	SD/PD*
3	5.35	−3.47	8.38	9.93	−4.51	SD
4	−27.15	−23.71	5.72	2.43	6.21	SD
5	−19.18	37.67	3.28	−12.81	11.65	SD
6	−7.72	−22.19	10.08	−19.42	10.04	PD
7	−28.17	−16.29	14.55	1.95	9.17	SD
8	−32.11	−15.96	4.68	0.64	−3.43	SD
9	−37.56	−3.74	6.12	21.37	22.80	SD
10	−13.95	−4.12	17.50	17.75	8.96	PR
11	−4.43	−7.94	15.56	−4.31	8.28	SD
12	−45.23	−21.59	7.96	−14.76	−1.37	SD
13	−47.67	−4.96	15.79	−6.40	10.69	SD
14	−46.51	−13.88	−4.55	−8.88	12.89	PR
15	8.25	3.75	−0.28	13.17	−1.10	SD
16	−24.17	7.50	−23.48	−6.78	5.19	PR
17	−55.76	9.58	−21.53	23.58	100.96	PR
18	−33.70	−19.41	−24.89	−3.03	−14.85	PR
Median % change of medians (interquartile range)	−25.99%(−39.48 to −6.90)(−55.76 to 123.94)	−6.45%(−17.07 to 3.83)(−23.71 to 37.67)	7.04%(−1.35 to 15.62)(−24.89 to 33.59)	−3.67%(−9.86 to 10.74)(−19.42 to 23.58)	8.62%(−1.89 to 11.96)(−14.85 to 100.96)	Summary SD = 11PR = 5PD = 1SD/PD = 1
P value for median % change(vs 0%)	P = .006	P = .06	P = .12	P = .80	P = .02	Summary SD = 11PR = 5PD = 1SD/PD = 1

Note:—Listed values are compared to 0% change (null value) for each of the 5 parameters. RANO response assessment key: PR indicates partial response; SD, stable disease; PD, progression of disease. For patient 2(*), the targeted treated primary tumor was classified as SD; however, new discontinuous leptomeningeal enhancement designated the overall response as PD.