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Overview of the most frequent brain and spinal MRI abnormalities according to disease type
Signal AlterationsEnlarged PVSHydrocephalus/VentriculomegalyAtrophySpinal Stenosis
MPS I
    Hurler+++++++++++++
    Hurler/Scheie+++++++++
    Scheie+++++++++
    MPS II+++++++++++++
MPS III
    IIIA++++++++
    IIIB++++++++–
    IIIC–––––
    IIID+±+–
MPS IV
    IVA±–±–+++
    IVB±–––+++
    MPS VI++++++++
    MPS VII++–––+
    MPS IX–––––
  • Note:—+++ indicates a constant finding; ++, a frequent finding; +, a less frequent finding; ±, rare; –, not described in the literature to our knowledge.