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Table 4: Regions of decreased qCBF in cognitively impaired patients with SPMS (PLS Analysis)
Cluster No. Brain Region Peak Voxel Coordinates^{^a} Cluster Size Bootstrap Ratio
1 Bilateral thalami (pulvinar) 4, −28, 4 303 7.20^{^b}
2 Bilateral medial frontal gyrus (BA 9) 0, 50, 22 74 6.92^{^b}
3 Right cingulate gyrus (BA 31) 18, −38, 42 42 6.50^{^b}
4 Right caudate body 10, 10, 6 163 6.28^{^b}
5 Left caudate body −12, −2, 14 62 5.91^{^b}
6 Right caudate tail 20, −18, 18 23 5.90^{^b}
↵a MNI space.
↵b P < .0001 (lower limit of significance).

Cluster No.	Brain Region	Peak Voxel Coordinates^{^a}	Cluster Size	Bootstrap Ratio
1	Bilateral thalami (pulvinar)	4, −28, 4	303	7.20^{^b}
2	Bilateral medial frontal gyrus (BA 9)	0, 50, 22	74	6.92^{^b}
3	Right cingulate gyrus (BA 31)	18, −38, 42	42	6.50^{^b}
4	Right caudate body	10, 10, 6	163	6.28^{^b}
5	Left caudate body	−12, −2, 14	62	5.91^{^b}
6	Right caudate tail	20, −18, 18	23	5.90^{^b}