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Table 3: Regions of decreased qCBV in cognitively impaired patients with SPMS (PLS Analysis)
Cluster No. Brain Region Peak Voxel Coordinates^{^a} Cluster Size Bootstrap Ratio
1 Bilateral thalami (pulvinar) 0, −28, 4 171 9.29^{^b}
2 Left caudate body −12, 6, 16 235 9.20^{^b}
3 Bilateral superior frontal gyri (BA 9) −2, 52, 24 64 9.02^{^b}
4 Bilateral superior frontal gyri (BA 6) 0, 22, 46 161 7.29^{^b}
5 Right caudate body 12, 10, 8 105 7.71^{^b}
6 Right corpus callosum 26, −46, 18 26 7.04^{^b}
7 Left caudate tail −20, −42, 8 111 6.63^{^b}
8 Right thalamus (pulvinar) 20, −36, 10 20 6.08^{^b}
↵a MNI space.
↵b P < .0001 (lower limit of significance).

Cluster No.	Brain Region	Peak Voxel Coordinates^{^a}	Cluster Size	Bootstrap Ratio
1	Bilateral thalami (pulvinar)	0, −28, 4	171	9.29^{^b}
2	Left caudate body	−12, 6, 16	235	9.20^{^b}
3	Bilateral superior frontal gyri (BA 9)	−2, 52, 24	64	9.02^{^b}
4	Bilateral superior frontal gyri (BA 6)	0, 22, 46	161	7.29^{^b}
5	Right caudate body	12, 10, 8	105	7.71^{^b}
6	Right corpus callosum	26, −46, 18	26	7.04^{^b}
7	Left caudate tail	−20, −42, 8	111	6.63^{^b}
8	Right thalamus (pulvinar)	20, −36, 10	20	6.08^{^b}