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Table 2: Conventional MRI features in patients with pediatric CIS and pediatric MS
Conventional MRI Features MRI at the Time of Presentation MRI at the Time of Diagnosis
MCIS PCISWOE PCISWE RRMS
Lesion location 
    Gray matter cortex 0 0 2 3
    BG and thalamus 0 2 6 12
    Subcortical 0 5 8 19
    Periventricular 1 7 4 20
    Perpendicular to CC 0 2 2 16
    Internal capsule 0 1 2 7
    Abutting the LV 0 0 0 10
    Cerebellum 0 0 4 12
    Brain stem 0 4 4 12
    Spinal cord 2 3 0 13
    Optic nerve 6 0 2 0
    No. of T2 lesions in the brain (range) 0–1 5–46 1–22 2–136
    No. of T2 lesions in the SC (range) 0–2 0–7 0–7 0–11
Lesion characteristics 
    Well-defined lesions 4 1 16
        Diffuse 1 8 10 22
        Ovoid 0 7 4 20
    Irregular-shaped 0 6 9 19
    Confluent 0 1 1 6
    Tumorlike 1 0 4 5
    Gd enhancement 6 1 1 6
    T1 black hole 0 0 0 11
Note:—BG indicates basal ganglia; LV, lateral ventricle; SC, spinal cord; Gd, gadolinium; CC, corpus callosum.