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Table 1: Imaging characteristics of patients with primary tumor among those with HPV+ oropharynx cancer and matched patients with HPV− oropharynx cancer
Imaging Characteristic HPV+ (n = 61) HPV− (n = 61) P Value
N % N %
Primary lesion is visible .362
    Yes 47 77.0 51 83.6 
    No 14 23.0 10 16.4 
Primary lesion is enhancing .182
    Yes 37 78.7 34 66.7 
    No 10 21.3 17 33.3 
Primary lesion demonstrates necrosis 8 17.0 7 13.7 .651
    Yes 39 83.0 44 86.3 
    No 
Primary lesion demonstrates well-defined border .067
    Yes 35 74.5 29 56.9 
    No 12 25.5 22 43.1 
Primary lesion is exophytic .095
    Yes 14 29.8 8 15.7 
    No 33 70.2 43 84.3 
Primary lesion demonstrates submucosal spread .667
    Yes 26 55.3 26 51.0 
    No 21 44.7 25 49.0 
Primary lesion invades adjacent muscle .013
    Yes 3 6.4 13 25.5 
    No 44 93.6 38 74.5

Imaging Characteristic	HPV+ (n = 61)		HPV− (n = 61)		P Value
Imaging Characteristic	N	%	N	%	P Value
Primary lesion is visible					.362
Yes	47	77.0	51	83.6
No	14	23.0	10	16.4
Primary lesion is enhancing					.182
Yes	37	78.7	34	66.7
No	10	21.3	17	33.3
Primary lesion demonstrates necrosis	8	17.0	7	13.7	.651
Yes	39	83.0	44	86.3
No
Primary lesion demonstrates well-defined border					.067
Yes	35	74.5	29	56.9
No	12	25.5	22	43.1
Primary lesion is exophytic					.095
Yes	14	29.8	8	15.7
No	33	70.2	43	84.3
Primary lesion demonstrates submucosal spread					.667
Yes	26	55.3	26	51.0
No	21	44.7	25	49.0
Primary lesion invades adjacent muscle					.013
Yes	3	6.4	13	25.5
No	44	93.6	38	74.5