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Table 2: Baseline MRI characteristics for all patients, split by progression status at 5 years^a
Sustained Disease Progression (n = 90) (mean) (SD) (median) Stable Disease (n = 90) (mean) (SD) (median) P Value
T2-LV 11.2 (12.9) 6.3 4.7 (5.5) 2.8 <.0001
NWBV 1488.8 (84.4) 1485.6 1524.4 (74.1) 1520.6 .003
NGMV 797.9 (53.1) 800.2 815.5 (50) 822.7 .02
NWMV 690.9 (49.9) 689.5 708.9 (37.4) 704.5 .007
NLVV 42.6 (15.1) 39.7 40 (11.8) 38.9 .3
NCV 623.6 (43.3) 627 639.7 (41.3) 643.6 .01
Total NSDGMV 44.5 (4.5) 44.5 46.6 (3.9) 46.4 .002
NSDGMV structures 
    Caudate nucleus 6.4 (0.8) 6.4 6.8 (0.8) 6.8 .0009
    Putamen 9.4 (1.1) 9.3 9.8 (1) 9.9 .015
    Globus pallidus 3.4 (0.4) 3.4 3.5 (0.4) 3.5 .05
    Thalamus 14.6 (1.8) 14.6 15.4 (1.5) 15.2 .002
    Hippocampus 7.2 (0.8) 7.2 7.5 (0.8) 7.6 .015
    Nucleus accumbens 0.9 (0.2) 0.9 1 (0.2) 1 .018
    Amygdala 2.6 (0.4) 2.6 2.6 (0.3) 2.6 .14
Note:—LV indicates lesion volume; NWBV, normalized whole-brain volume; NGMV, normalized gray matter volume; NWMV, normalized white matter volume; NLVV, normalized lateral ventricle volume; NCV, normalized cortical volume; NSDGMV, normalized subcortical deep gray matter volume.
↵a The difference of the means between the groups was calculated using Student t test. The MRI volumes are presented in milliliters.