1naresh
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Sustained Disease Progression (mean) (SD) (median) Stable Disease (mean) (SD) (median) P Value T2-LV (No. patients) 80 78 Absolute change 2.8 (6.3) 1.6 2.3 (3.8) 1.0 % Change 53.9 (66.7) 36.3 79.1 (156.4) 40.5 .4 Whole-brain (No. patients) 82 80 % Change −4.8 (3.4) −3.9 −2.6 (2) −2.2 <.0001 Gray matter (No. patients) 82 79 % Change −5.3 (3.1) −4.5 −3.8 (2.3) −4.1 .003 White matter (No. patients) 82 79 % Change −0.9 (3.4) −0.5 0.4 (3.1) 0.8 .06 Lateral ventricle volume, (No. patients) 82 79 % Change 26.7 (24.8) 22.6 14.9 (11.3) 13.4 .02 Cortical volume (No. patients) 80 78 % Change −5.4 (3.1) −4.9 −3.8 (2.2) −4 .001
Note:—T2-LV indicates T2-lesion volume.
↵a The difference between the groups was calculated using regression analysis adjusting for age, disease duration, and change of treatment status during the 5-year follow-up. The absolute volume changes are presented in milliliters. Variables with skewed distributions (% change in T2-LV and % change in LV) were transformed using Box-Cox transformations. The changes between baseline and follow-up scans for whole-brain, gray matter, white matter, lateral ventricle, and cortical volume were calculated using the direct-measurement technique; hence, no absolute but only percentage volume changes are available.