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Table 4: Effects of age, APOE ε4, and sex on rates of change in AD
AD Measure b₀ b_Cog b_Edu b_Age (SE; P) b_APOE (SE; P) b_Sex (SE; P)
Hippocampus −2.80^a −0.06^a 0.03 0.06^a (.03; .028) −0.62 (.35; .08) −0.49 (.30; .1)
Amygdala −2.73^a −0.05 0.06 0.06^a (.03; .043) −0.91^a (.36; .012) −0.41 (.31; .2)
Entorhinal −2.65^a −0.04 −0.02 0.04^a (.02; .045) −0.43 (.25; .09) −0.49^a (.22; .025)
Inferior parietal −1.68^a −0.06^a −0.03 0.15^a (.02; <10⁻⁶) −0.25 (.24; .3) −0.69^a (.21; .001)
Middle temporal −2.48^a −0.10^a −0.05 0.17^a (.02; <10⁻⁶) −0.30 (.29; .3) −0.88^a (.25; .001)
Med-orbito-frontal −0.96^a −0.02 −0.02 0.05^a (.02; .008) 0.04 (.24; .9) −0.64^a (.21; .002)
Whole brain −0.97^a −0.04^a −0.01 0.06^a (.01; <10⁻⁶) −0.19 (.14; .2) −0.38^a (.12; .002)
CDR-SB 1.39^a – 0.11^a 0.01 (.03; .8) 0.27 (.33; .4) 0.10 (.29; .7)
ADAS-Cog 3.20^a – 0.29 −0.15 (.08; .069) 1.25 (.98; .2) 0.49 (.89; .6)
MMSE −1.97^a – −0.16 0.13^a (.05; .007) −0.20 (.57; .7) 0.03 (.52; 1.0)
Note:—See Table 2 for units and key.
↵a Values significant at P ≤ .05.
ROIs: N = 105; mean age = 75.74 years; mean ADAS-Cog = 18.49; mean years education = 14.83. Cognitive: N = 144; mean age = 75.99 years; mean years education = 14.70.