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Table 1: Summary of demographics for patients with SMART
Patient Radiation Indication Interval, y Age at Diagnosis, y Seizures Before Seizure With Headache Before Headache With Therapies Used
1 Pituitary lesion 22 60 ? Y N N Phenytoin, levetiracetam
2 Pineal tumor 30 42 Y N ? Y Corticosteroids
3 Astrocytoma 32 44 N N ? Y Verapamil, phenytoin
4 Oligoastrocytoma 14 53 Y Y N N Phenytoin, levetiracetam
5 Dysgerminoma 19 50 N N Y Y Corticosteroids
6 Fibrillary astrocytoma 13 45 Y Y N N Levetiracetam, valproate, corticosteroids
7 Astroblastoma 27 58 Y N N Y Phenytoin, aspirin
8 Lymphoma 16 37 N Y Y Y Levetiracetam, verapamil, aspirin
9 Oligoastrocytoma 10 50 N Y Y Y Levetiracetam, verapamil, corticosteroids
10 Metastatic melanoma 6 50 Y Y N Y Levetiracetam, verapamil, corticosteroids
11 Brain stem glioma 30 58 N Y Y Y Levetiracetam, verapamil
Note:—“Interval” indicates the interval in years between radiotherapy and the diagnosis of SMART. “Seizures before” and “Seizure with,” “Headache before” and “Headache with” refer to symptoms preceding initiation and during SMART episodes, respectively.