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Characteristics of adults with ataxia-telangiectasia
Participant Age/Sex Age of Onset^a AFP^b (ng/mL) Chromatid Breaks/Cell^c SWI Lesions WM T2 Hyperintensity Additional MRI Findings
1 21/F 1 498 2.02 Multiple None −
2 21/F 1 123 NA 1 None −
3 25/F 2 1 2.20 None None −
4 20/M 1 400 NA Multiple None −
5 22/M 3 240 NA Multiple None −
6 23/F 1.5 224 1.48 Several None −
7 19/F 2 14 1.34 None None −
8 21/F 1.5 384 2.58 None None −
9 34/M 3 484 2.14 Innumerable Present −
10 28/M 2 715 1.92 Innumerable Present Cystic mass
Note:—NA indicates not available.
↵a Age (years) at first inquiry to physician for neurologic concern.
↵b Normal < 10 ng/mL.
↵c Measured after in vitro exposure to x-irradiation (1.0 Gy); normal range, 0.06-0.34 (Thomas GH and Lederman HM, personal communication).

Participant	Age/Sex	Age of Onset^a	AFP^b (ng/mL)	Chromatid Breaks/Cell^c	SWI Lesions	WM T2 Hyperintensity	Additional MRI Findings
1	21/F	1	498	2.02	Multiple	None	−
2	21/F	1	123	NA	1	None	−
3	25/F	2	1	2.20	None	None	−
4	20/M	1	400	NA	Multiple	None	−
5	22/M	3	240	NA	Multiple	None	−
6	23/F	1.5	224	1.48	Several	None	−
7	19/F	2	14	1.34	None	None	−
8	21/F	1.5	384	2.58	None	None	−
9	34/M	3	484	2.14	Innumerable	Present	−
10	28/M	2	715	1.92	Innumerable	Present	Cystic mass